Gold-Catalyzed 1,2-Aminoarylation of Alkenes with External Amines

Reported
herein is the gold-catalyzed 1,2-aminoarylation of alkenes
that engages external amine as a coupling partner. Careful optimization
studies revealed a significant role of the concentration of base to
achieve highly chemoselective access to the aminoarylation products
over potential C–N cross-coupled products. Overcoming all the
limitations, the current strategy provided straightforward access
to the medicinally relevant 3-aminochroman, 2-aminotetra­hydro­naphthalene,
and 2-aminoindane derivatives.