Antimicrobial Triterpenoids from <i>Vladimiria muliensis</i>

A new triterpenoid with a rearranged ursane skeleton, 3β-acetoxyl-11α-methoxybauer-8-en-7α-ol (1), two new ursane triterpenoids, 1α,5α-dioxy-11α-hydroxyurs-12-en-3-one (2) and urs-3β,13α,18β-triol (3), together with three known ursane triterpenoids (4–6) were isolated from the rhizome of Vladimiria muliensis. Their structures were elucidated on the basis of spectroscopic methods (IR, EIMS, HRESIMS, 1D and 2D NMR, and X-ray crystallography diffraction). Compounds 2 and 4 exhibited modest antimicrobial activity against Escherichia coli, Candida albicans, Pseudomonas aeruginosa, Enterococcus faecalis, Bacillus cereus, and Staphylococcus aureus.