Effect of sensor location on continuous intraperitoneal glucose sensing in an animal model

In diabetes research, the development of the artificial pancreas has been a major topic since continuous glucose monitoring became available in the early 2000's. A prerequisite for an artificial pancreas is fast and reliable glucose sensing. However, subcutaneous continuous glucose monitoring carries the disadvantage of slow dynamics. As an alternative, we explored continuous glucose sensing in the peritoneal space, and investigated potential spatial differences in glucose dynamics within the peritoneal cavity. As a secondary outcome, we compared the glucose dynamics in the peritoneal space to the subcutaneous tissue.

Eight-hour experiments were conducted on 12 anesthetised non-diabetic pigs. Four commercially available amperometric glucose sensors (FreeStyle Libre, Abbott Diabetes Care Ltd., Witney, UK) were inserted in four different locations of the peritoneal cavity and two sensors were inserted in the subcutaneous tissue. Meals were simulated by intravenous infusions of glucose...

自21世纪初连续血糖监测（continuous glucose monitoring）技术问世以来，人工胰腺（artificial pancreas）的研发始终是糖尿病研究领域的核心议题。人工胰腺的核心先决条件是实现快速且可靠的血糖传感，但皮下连续血糖监测存在动力学响应迟缓的固有弊端。为此，本研究探索了腹膜腔（peritoneal space）内的连续血糖传感方案，并探究了腹腔内血糖动力学的潜在空间差异；作为次要研究终点，本研究还对比了腹膜腔与皮下组织内的血糖动力学特征。

本研究对12只麻醉状态下的非糖尿病家猪开展了时长8小时的动物实验：将4台商用安培式血糖传感器（amperometric glucose sensor，型号为FreeStyle Libre，由英国威特尼的雅培糖尿病护理有限公司（Abbott Diabetes Care Ltd.）生产）分别植入腹膜腔的4个不同位置，另2台传感器植入皮下组织，通过静脉输注葡萄糖来模拟进食过程……