Supplementary Material for: Testosterone Therapy for Late-Onset Hypogonadism Improves Erectile Function: A Systematic Review and Meta-Analysis

<b><i>Introduction:</i></b> Randomized controlled trials (RCTs) of testosterone therapy (TTh) for late-onset hypogonadism are systematically reviewed and a meta-analysis to assess the efficacy of TTh in improving erectile function is performed. <b><i>Methods:</i></b> The PubMed, Cochrane Library, and Web of Science databases were searched to identify RCTs published from 2007. RCTs that assessed erectile function using the erectile function domain of the International Index of Erectile Function (IIEF-EFD) were included in the meta-analysis. <b><i>Results:</i></b> The systematic review included 18 RCTs and the meta-analysis included 6 studies that enrolled a total of 1,458 patients. The overall meta-analysis revealed that the IIEF-EFD score was significantly improved in the TTh group compared with the placebo group (mean difference 1.86; 95% confidence interval 1.01–2.72; <i>p</i> &lt; 0.0001). Compared with patients receiving placebo, there was a significant improvement in the IIEF-EFD of patients who received TTh using testosterone gel, those who received TTh for over 30 weeks, and those without diabetes mellitus or metabolic syndrome. <b><i>Conclusion:</i></b> TTh achieved a significant improvement in the IIEF-EFD score of hypogonadal men compared with placebo, especially in those who received testosterone gel, were treated for over 30 weeks, and had no comorbidities.

<b><i>引言：</i></b> 本研究针对迟发性性腺功能减退症的睾酮治疗（Testosterone Therapy, TTh）相关随机对照试验（Randomized Controlled Trials, RCTs）进行系统综述，并开展荟萃分析以评估睾酮治疗改善勃起功能的疗效。<b><i>方法：</i></b> 检索PubMed数据库、Cochrane图书馆及Web of Science数据库，筛选2007年以来发表的相关随机对照试验。纳入采用国际勃起功能指数-勃起功能域（International Index of Erectile Function, IIEF-EFD）评估勃起功能的研究进行荟萃分析。<b><i>结果：</i></b> 本系统综述共纳入18项随机对照试验，荟萃分析纳入6项研究，合计1458例患者。总体荟萃分析结果显示，与安慰剂组相比，睾酮治疗组的国际勃起功能指数-勃起功能域评分显著提升（均数差1.86；95%置信区间1.01~2.72；P < 0.0001）。相较于安慰剂组患者，接受睾酮凝胶治疗的受试者、治疗时长超过30周的受试者以及无糖尿病或代谢综合征的受试者，其国际勃起功能指数-勃起功能域评分均出现显著改善。<b><i>结论：</i></b> 与安慰剂相比，睾酮治疗可显著改善迟发性性腺功能减退男性的国际勃起功能指数-勃起功能域评分，尤其在使用睾酮凝胶、治疗时长超过30周且无合并症的患者中改善效果更为突出。