Mus musculus Transcriptome or Gene expression

Leptin resistance during excess weigh gain significantly contributes to the recidivism of obesity to leptin-based pharmacological therapies. The mechanisms underlying the inhibition of Leptin receptor b (LepR) signaling during obesity is still elusive. Here we are going to identify the gene networks involved in the leptin sensitizer-celastrol vs pair-feeding condition from hypothalamus of diet indued obese mice.