Phosphorylation of AXN and APC by SGG

Additional phosphorylation of the scaffolding molecules, Axin (AXN) and APC (APC/APC2), is carried out by the GSK3beta kinase orthologue Shaggy (SGG) with Ser1501 (also a priming phosphorylation) in Human APC and Ser614 and Thr609 in Mouse Axin (equivalent to Ser522 and Thr517 respectively in Fly and Ser524 and Thr519 in Human).

骨架分子Axin（AXN）和APC（APC/APC2）的额外磷酸化由GSK3beta激酶同源物Shaggy（SGG）执行，其中在人类APC中为Ser1501（亦为启动磷酸化），在鼠Axin中为Ser614和Thr609（分别对应果蝇中的Ser522和Thr517，以及人类中的Ser524和Thr519）。