A Virtual Library for Behavioral Performance in Standard Conditions – Experiment 29 Q17 Differential effects of clorgyline (a MAO inhibitor) on sensitization to QNP in rats tested in small and large environments

Beyond their specific experiment, video records of behavior have future value; for example, as inputs for new experiments or for yet unknown types of analysis of behaviorsimilar to tissue or blood sample banks in life sciences where clinically-derived or otherwise well-described experimental samples are stored to be available for some unknown potential future purpose. <br>Research using an animal model of obsessive-compulsive disorder employed a standardized paradigm where the behavior of rats in a large open field was video recorded for 55 min on each test. From 43 experiments, there are 19,976 such trials that amount to over 2 years of continuous recording. In addition to videos, there are two video-derived raw data objects: XY locomotion coordinates, and plots of animal trajectory. To motivate future use, the three raw data objects are annotated with a general schemaone that abstracts the data records from their particular experiment while providing, at the same time a detailed list of independent variables bearing on behavioral performance. The raw data objects are deposited as 43 datasets but constitute, functionally, a library containing one large dataset. <br>Size and annotation schema give the library high re-use potential: in applications using machine learning techniques, statistical evaluation of subtle factors, simulation of new experiments, or as educational resource. Ultimately, the library can serve both as the seed and the test bed to create a machine searchable virtual library of linked open datasets for behavioral performance in defined conditions.

除却其依附的特定实验场景外，行为视频记录具备长期复用价值：既可作为新实验的输入数据，亦可用于未来尚未明确的行为分析场景——这与生命科学领域的组织或血液样本库逻辑相通：该类样本库会储存临床来源或经过详尽描述的实验样本，以备未来未知的潜在研究需求。<br>本数据集基于强迫症（Obsessive-Compulsive Disorder, OCD）动物模型的相关研究，采用标准化实验范式：在大型旷场装置中，对每一次测试中大鼠的行为进行55分钟的视频录制。该数据源自43项独立实验，共计19976次测试，累计连续录制时长超过2年。除视频文件外，数据集还包含两类由视频衍生的原始数据对象：大鼠运动的XY坐标轨迹，以及动物运动路径绘图。为便于未来复用，三类原始数据对象均基于通用标注框架完成标注：该框架既可以将数据记录脱离其所属的特定实验场景进行抽象，同时又能完整列出与行为表现相关的全部自变量细节。尽管原始数据对象以43个独立数据集的形式归档存储，但从功能层面而言，它们共同构成了一个整合了完整大型数据集的资源库。<br>数据集的规模与标注框架赋予该资源库极高的复用潜力：可应用于机器学习技术相关研究、细微影响因素的统计评估、新实验的模拟推演，亦可作为教学资源使用。从长远来看，该资源库可同时充当两大角色：一是作为构建面向既定实验条件下行为表现的可机器检索关联开放数据集虚拟库的雏形，二是作为该虚拟库的测试平台。