The T-cell leukemia homeobox 1 (TLX1, HOX11) transcription factor is critically involved in the multistep pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL) and often cooperates with NOTCH1 a
We are studying the transcriptome of the acute myeloid leukaemia (AML) cell line THP-1, including transcriptome assembly and variant calling, for use in an integrated analysis of the immunopeptidome i
We characterized the marine natural product cortistatin A (CA) as an inhibitor of CDK8 to determine whether pharmacologic inhibition of CDK8 regulates super-enhancer function and inhibits AML prolifer
