Cognitive correlates of cerebellar resting-state functional connectivity in Parkinson disease.

Objective: The purpose of this cross-sectional study was to investigate the contributions of altered cerebellar resting-state functional connectivity (FC) to cognitive impairment in Parkinson disease (PD).

Methods: We conducted morphometric and resting-state functional connectivity MRI (FC-MRI) analyses contrasting 81 PD and 43 age-matched healthy controls using rigorous quality assurance measures. To investigate the relationship of cerebellar FC to cognitive status, we compared PD participants without cognitive impairment (Clinical Dementia Rating scale, CDR=0; n=47) to PD participants with impaired cognition (CDR≥0.5; n=34). Comprehensive measures of cognition across the five cognitive domains were assessed for behavioral correlations.

Results: The PD participants had significantly weaker FC between the vermis and peristriate visual association cortex compared to controls, and the strength of this FC correlated with visuospatial function and global cognition. In contrast, weaker...

研究目的：本横断面研究（cross-sectional study）旨在探讨小脑静息态功能连接（resting-state functional connectivity，FC）异常对帕金森病（Parkinson disease，PD）患者认知损害的影响。
研究方法：本研究通过严格的质量控制流程，对81例帕金森病患者与43例年龄匹配的健康对照人群开展形态学测量及静息态功能磁共振成像（resting-state functional connectivity MRI, FC-MRI）分析。为探究小脑FC与认知状态的关联，本研究将无认知损害的帕金森病患者（临床痴呆评定量表（Clinical Dementia Rating scale, CDR）评分=0；n=47）与存在认知损害的帕金森病患者（CDR评分≥0.5；n=34）进行分组对比，并针对五大认知领域的综合认知测评结果开展行为学相关性分析。
研究结果：相较于健康对照人群，帕金森病患者的小脑蚓部与纹周视觉联合皮层之间的FC显著减弱，且该FC强度与视空间功能及整体认知水平呈显著相关。与之相反，减弱的……