Predictors of nephrolithiasis, osteoporosis and mortality in primary hyperparathyroidism

Context: Primary Hyperparathyroidism (PHPT) has a prevalence of 0.86% and is associated with increased risk of nephrolithiasis and osteoporosis. PHPT may also be associated with an increased risk of cardiovascular disease and mortality.
Objective: To identify risk factors for nephrolithiasis, osteoporosis and mortality in PHPT.
Design: Retrospective cohort study.
Setting: University teaching hospital.
Patients: PHPT presenting between 2006 – 2014 (n = 611).
Main outcome measures: Assessment of nephrolithiasis, osteoporosis and mortality.
Results: 13.9% of PHPT patients had nephrolithiasis. Most had already documented stone disease and only 4.7% of asymptomatic patients screened for renal stones had calculi identified, not very dissimilar to the rate in the non-PHPT population. Younger age (P < 0.001) and male gender (P = 0.003) were the only independent predictors of nephrolithiasis.
48.4% of patients with DXA data had osteoporosis (223/461). Older age (P < 0.001),...

背景：原发性甲状旁腺功能亢进症（Primary Hyperparathyroidism, PHPT）的患病率为0.86%，与肾结石病、骨质疏松症的发病风险升高相关，同时还可能增加心血管疾病及死亡风险。
研究目的：明确原发性甲状旁腺功能亢进症患者发生肾结石病、骨质疏松症及死亡的危险因素。
研究设计：回顾性队列研究。
研究场景：大学教学医院。
研究对象：2006年至2014年间就诊的原发性甲状旁腺功能亢进症患者（n=611）。
主要结局指标：对肾结石病、骨质疏松症及死亡情况进行评估。
结果：13.9%的原发性甲状旁腺功能亢进症患者合并肾结石病，其中多数已确诊结石病；仅4.7%接受肾结石筛查的无症状患者检出结石，该比例与非原发性甲状旁腺功能亢进症人群差异不大。较年轻的年龄（P<0.001）与男性性别（P=0.003）是肾结石病仅有的独立预测因素。
48.4%的具备双能X线骨密度检测（DXA）数据的患者合并骨质疏松症（223/461）。高龄（P<0.001）……