Synergistic drug interaction between gossypol and gemcitabine.

Combination treatment of masitinib and gemcitabine was tested on nasopharyngeal (n = 4), breast (n = 3) and gastric (n = 3) cancer cell lines. Combination index (CI) were generated by Calcusyn software for combination of gossypol and gemcitabine. CI *indicates gemcitabine resistance cell lines. High/low Bcl-2 expression is defined by the presence or absence of Bcl-2 expression based on immunoblot of the gene.