Zika virus remodels the IGF2BP2 and VCP cellular interactome

Zika virus (ZIKV) infection causes significant human disease that, with no approved treatment or vaccine, constitutes a major public health concern. Its life cycle entirely relies on the cytoplasmic fate of the viral RNA genome (vRNA) through a fine-tuned equilibrium between vRNA translation, replication and packaging into new virions, all within virus-induced replication organelles (vRO). In this study, we characterized the cellular interactome of insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and the valosin-containing protein (VCP, also known as p97)