Modulatory Role of Pantropic Cell Signaling Pathways in the Antimigratory and Antiproliferative Action of Triazole Chelated Iridium(III) Complexes in Cervical Cancer Cells

In the current study, the antimigratory and antiproliferative
effect
of three substituted triazole-chelated iridium(III) complexes Ir-TRN,
Ir-TRH, and Ir-TRF were studied with special emphasis on modulation
of P53 activity, a cell cycle regulator. ERK2/MAPK, another crucial
cell signaling pathway protein, was also shown to play a crucial role
in cell migration and proliferation. The complexes increase the ROS
generation within the cell, further supporting apoptotic induction
by exerting cellular oxidative stress. These metal complexes also
affect ER stress by altering ERp29, an ER-resident chaperone, further
inducing the process of apoptosis. The iridium(III) complexes restrict
cervical cancer cell migration and proliferation by exerting pronounced
effects as P53 activators and downregulation of ERK2/MAPK activity
in cervical cancer cells. The underpinning mechanism of P53 and ERK2/MAPK
activity in cervical cancer cells in the presence of iridium(III)
complexes was studied in detail in this study, which paves the way
for developing promising avenues for cancer therapeutics.