Consensus on the investigation of thrombophilia in women and clinical management

ABSTRACT Objective To standardize the investigation and clinical management of women with laboratory and/or clinical abnormalities suggestive of thrombophilia, in order to optimize antithrombotic approach and indication of laboratory tests. Methodology A discussion was carried out among 107 physicians (gynecologists/obstetricians, hematologists and vascular surgeons) present at a forum held at the Hospital Israelita Albert Einstein, in São Paulo (SP), Brazil. As a minimum criterion, 80% agreement was established in the voting to each recommendation of conduct in the final document. The cases in which there was agreement below 80% were discussed again, reaching a consensual agreement of conduct for the document writing. Conclusion The standardization of an institutional consensus of suggestions of clinical approach contributes to a better management of the group to be evaluated and minimizes risks of intercurrent events. This was the first national consensus on the investigation of thrombophilia in women.

摘要
目的：规范伴有提示血栓形成倾向（thrombophilia）的实验室与/或临床异常女性患者的调查及临床管理流程，以优化抗血栓诊疗方案及实验室检查指征。
研究方法：于巴西圣保罗州（SP）以色列阿尔伯特·爱因斯坦医院举办的学术论坛中，召集107名医师（涵盖妇产科医师、血液科医师与血管外科医师）开展研讨。本次研讨设定最低共识标准：最终文件中的每项诊疗建议需获得80%及以上的投票同意率。对于投票同意率低于80%的案例，将进行再次讨论，直至达成可用于文件撰写的共识性诊疗方案。
结论：制定机构层面的临床诊疗建议共识规范，有助于提升待评估人群的管理质量，并降低并发不良事件的风险。本共识为巴西首个针对女性血栓形成倾向调查的全国性共识。