Tag single nucleotide polymorphisms (SNPs) in CYP1B1 - investigation of effect on Primary Open Angle Glaucoma (POAG) dataset

This dataset comprises cleaned, standard genetics data of the CYP1B1 gene from 1810 samples. Seven tag single nucleotide polymorphisms (SNPs), including two coding variants (L432V and N543S), were genotyped in 860 primary open angle glaucoma (POAG) cases and 898 examined normal controls. Each SNP and haplotype was assessed for association with disease.Relevant column headings for the *.ped file are:Family IDIndividual IDFather IDMother IDSexAffection statusThen the remainder describe genotypes at single nucleotide polymorphisms, as described in the *.map file, 2 columns per SNPIn the *.map file:ChromosomeSNP namePosition in centiMorgansPosition in basepairsDate coverage: 2010-01-01 - 2010-06-30Location: Australia

本数据集包含1810份样本中经过清洗与标准化处理的CYP1B1基因遗传学数据。研究对7个标签单核苷酸多态性（single nucleotide polymorphisms, SNPs）位点完成了基因分型，其中包含2个编码变异位点L432V与N543S，样本群体涵盖860例原发性开角型青光眼（primary open angle glaucoma, POAG）患者及898例经临床检查确认的正常对照个体。本研究对每一个单核苷酸多态性位点及单体型与疾病的关联进行了评估。
*.ped文件的相关列标题依次为：家系ID、个体ID、父亲ID、母亲ID、性别、患病状态；剩余列则按照*.map文件的说明，以每2列对应一个单核苷酸多态性位点的格式，描述各样本的基因型信息。
*.map文件包含以下列：染色体编号、单核苷酸多态性位点名称、厘摩（centiMorgans）位置、碱基对位置。
本数据集的覆盖时段为2010年1月1日至2010年6月30日，研究地点为澳大利亚。