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Single-cell RNA expression profiling of mouse common lymphoid progenitors with or without dox-induction of LIN28B

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NIAID Data Ecosystem2026-04-25 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP126827
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To reprogram adult HSPCs in vivo, we used a mouse engineered to express LIN28B in a Doxycycline (Dox)-inducible manner (iLIN28B). We performed single cell RNA-seq to compare the transcriptomes of common lymphoid progenitor (CLP) cells isolated from mouse FL, adult BM of wildtype mice, adult BM of iLIN28B treated with Dox (+Dox), and adult BM of littermate controls +Dox. Overall design: 4 Chromium Single Cell 3' llbraries were prepared and sequenced from CLP populations as described above.
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2019-09-28
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