Enantioselective Deprotonative Ring Contraction of N1‑Methyl‑N4‑Boc-benzo[e][1,4]diazepine-2,5-diones
收藏Figshare2016-02-16 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Enantioselective_Deprotonative_Ring_Contraction_of_i_N_i_1_Methyl_i_N_i_4_Boc_benzo_i_e_i_1_4_diazepine_2_5_diones/2249971
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N1-Methyl-N4-Boc-benzo[e][1,4]diazepine-2,5-diones were prepared in good yield and high stereochemical purity from five amino acids. Upon deprotonation, these compounds undergo ring contraction to the corresponding quinolone-2,4-diones with high enantioselectivity, providing efficient entry to a potentially useful drug scaffold. Mechanistic commentary and comparisons to related reactions are provided.
创建时间：
2016-02-16
