Supplementary Material for: HyperCKemia in Guillain-Barré Syndrome

The aim of the present study was to investigate the frequency and clinical features of Guillain-Barré syndrome (GBS) with hyperCKemia. We retrospectively identified 139 patients with GBS at 2 teaching hospitals in South Korea. We excluded patients with Miller-Fisher syndrome (<i>n</i> = 19), acute bulbar palsy (<i>n</i> = 3), and those whose serum creatine kinase (CK) levels were not measured (<i>n</i> = 45). Twelve of 72 patients (16.7%) had transient hyperCKemia, defined as serum CK ≥300 IU/L. The frequency of male sex and non-demyelinating electrodiagnostic features were higher in patients with hyperCKemia than those without. Transient hyperCKemia, occasionally seen in patients with GBS may be associated with the non-demyelinating subtype.

本研究旨在探讨伴高肌酸激酶血症（hyperCKemia）的吉兰-巴雷综合征（Guillain-Barré syndrome, GBS）的发病频率与临床特征。我们在韩国两家教学医院回顾性确认了139例吉兰-巴雷综合征患者，随后排除米勒-费希尔综合征患者（n=19）、急性球麻痹患者（n=3）以及未检测血清肌酸激酶（CK）水平的患者（n=45）。最终纳入分析的72例患者中，12例（16.7%）出现一过性高肌酸激酶血症，其定义为血清CK水平≥300 IU/L。与无高肌酸激酶血症的患者相比，伴高肌酸激酶血症患者的男性占比及非脱髓鞘电诊断特征占比更高。吉兰-巴雷综合征患者中偶见的一过性高肌酸激酶血症，可能与非脱髓鞘亚型相关。