Profile of oncological diseases in dogs and clinical effectiveness of autovaccine therapy of papillomatosis

ABSTRACT Papillomatosis is one of the few diseases in which autovaccine therapy is recommended, especially in the case of mass manifestation in animals. It is noted that papillomas are diagnosed in 15.7% of cases in histological diagnosis of oncological diseases. Therefore, this work studied the profile of oncological diseases in dogs and the clinical effectiveness of autovaccine therapy of papillomatosis. The article gives a morphological description of papillomas used as a biomaterial, and also describes the technological methods of manufacturing an autovaccine used to treat animals against papillomatosis. A therapeutic scheme for administering the vaccine was proposed and tested, and the results of the clinical trial are presented, as well as a reflection on some moments of the mechanism of vaccine therapy for papillomatosis.

摘要 乳头瘤病（Papillomatosis）是少数推荐采用自体疫苗疗法（autovaccine therapy）的疾病之一，尤其适用于动物出现大面积发病的场景。研究表明，在肿瘤疾病的组织学诊断（histological diagnosis）中，15.7%的病例被确诊为乳头状瘤。为此，本研究围绕犬类肿瘤疾病的发病特征，以及乳头瘤病自体疫苗疗法的临床有效性展开了系统探究。本文对作为生物材料（biomaterial）使用的乳头状瘤进行了形态学描述，并详细阐明了用于治疗动物乳头瘤病的自体疫苗的制备工艺流程。研究提出并验证了该疫苗的给药方案，同时展示了临床试验的最终结果，还对乳头瘤病疫苗疗法的部分作用机制相关问题进行了深入探讨。