Five Substances Powder with Poria ameliorates lipid metabolic disorders in obese mice by modulating gastric inhibitory polypeptide release via intestinal microbiota regulation

Obesity is a chronic metabolic disorder that increases the risk of various metabolic diseases, such as type 2 diabetes and metabolic dysfunction-associated steatohepatitis (MASH). While previous studies have shown that Five Substances Powder with Poria can alters gut microbiota to improve glycolipid metabolism and obesity, the underlying mechanisms still need to be clarified. The present study aimed to explore the potential mechanisms of Five Substances Powder with Poria in suppressing obesity more deeply through an integrated research strategy. Overall design: RNA-seq analysis of the small intestine of mice in the ND, HFD and Five Substances Powder with Poria groups (N, H, H1)