Ocular manifestations of psoriasis

ABSTRACT Purpose: We aimed to report the ocular manifestations observed in patients with psoriasis. Methods: Patients were included and referred to our ophthalmology clinic from dermatology clinics of Universidade do Estado do Pará between October 2013 and August 2014. Clinical interviews were conducted to identify relevant epidemiological data, clinical features, and treatment details, and data were recorded using the same protocol. Subsequent dermatological examinations were performed and disease severity was rated using the Psoriasis Area and Severity Index and the Dermatological Life Quality Index. Complete eye examination was conducted, including visual acuity, biomicroscopy, tonometry, fundoscopy, Schirmer I test, tear breakup time, rose bengal staining, ocular surface disease index, and glaucoma tests. Results: In total, we included 43 patients with psoriasis and 86 controls. Patients with psoriasis had statistically higher incidences of dry eye (16.28%), likely dry eye (32.56%), and blepharitis (16.28%). Furthermore, the rose bengal and ocular surface disease tests were more abnormal in patients with psoriasis (p<0.05). Conclusions: Patients with psoriasis should undergo regular eye exams, regardless of risk factors, to monitor for the progression of symptomatic or asymptomatic ocular manifestations.

摘要
目的：本研究旨在报告银屑病患者的眼部临床表现。
方法：2013年10月至2014年8月期间，从帕拉州立大学皮肤科转诊至本院眼科门诊的银屑病患者被纳入本研究。通过临床访谈收集相关流行病学资料、临床特征及治疗细节，并采用统一研究方案记录所有数据。随后对受试者进行皮肤科检查，以银屑病面积与严重程度指数（Psoriasis Area and Severity Index, PASI）及皮肤病生活质量指数（Dermatological Life Quality Index, DLQI）评估疾病严重程度。同时完成全套眼科检查，涵盖视力检查、裂隙灯生物显微镜检查、眼压测量、眼底镜检查、席默尔I试验（Schirmer I test）、泪膜破裂时间检测、孟加拉玫瑰红染色、眼表疾病指数（Ocular Surface Disease Index, OSDI）检测及青光眼相关检测。
结果：本研究共纳入43例银屑病患者及86例健康对照受试者。银屑病患者的干眼症（16.28%）、疑似干眼症（32.56%）及睑缘炎（16.28%）发生率显著高于对照组，差异具有统计学意义。此外，银屑病患者的孟加拉玫瑰红染色及眼表疾病指数检测结果异常率更高（p<0.05）。
结论：无论是否存在眼部危险因素，银屑病患者均应定期接受眼科检查，以监测有症状或无症状眼部表现的进展。