EPA's Toxicity Reference Database

ToxRefDB was developed by the National Center for Computational Toxicology (NCCT) in partnership with EPA's Office of Pesticide Programs (OPP), to store data from in vivo animal toxicity studies. The database:

-Contains pesticide registration toxicity data that used to be stored as hard-copy and scanned documents by OPP.
-Currently includes chronic, cancer, sub-chronic, developmental, and reproductive studies on hundreds of chemicals (many are pesticide active ingredients).
-Provides data that is accessible and computable.
-Provides reference toxicity data for Agency research and retrospective analyses.
-Provides toxicity endpoints for development of ToxCast predictive signatures that will be used for primary research applications.
-Contains only certain hazard information and does not represent all information needed for a complete risk assessment for pesticides or other chemicals.
-Effect designation should not be taken as determination that existing EPA risk assessments and risk management decisions need revisions.

For example, in addition to studies in ToxRefDB, for purposes of registration or tolerance determination, EPA evaluated information on other mammalian toxicity effects, metabolism, aquatic life, wildlife and plant toxicity studies, and use patterns, environmental fate and persistence, and pesticide residue levels.