S100A4/TCF complex transcription regulation drives epithelial-mesenchymal transition in chronic sinusitis through Wnt/GSK-3β/β-catenin signaling

Chronic rhinosinusitis (CRS) is closely associated with remodelling of nasal mucosal tissue during a prolonged inflammatory process, and epithelial mesenchymal transition (EMT) is thought to be involved in this process, but the underlying mechanisms driving this progression are unclear. Using a high-resolution Q Exactive Plus Orbitrap mass spectrometer, we performed a proteomic screen of CRS nasal mucosal tissue to identify differentially expressed proteins.