HBCx_22_scChIPseq_mm10_50kb.tsv

The samples correspond to the mouse cells from patient-derived xenograft (PDX) originating from two different human donors. The HBCx-22 and HBCx-22-TamR datasets correspond to mouse cells from a pair of luminal ER⁺ breast PDXs: HBCx-22, responsive to Tamoxifen and HBCx-22-TamR, resistant to Tamoxifen. The HBCx-95 and HBCx-95-CapaR correspond to a triple-negative breast cancer (TNBC) tumor model of acquired resistance to chemotherapy. Row names of the matrices are 50,000-bp binned regions; Column names are barcodes corresponding to single cell; Cells contains raw counts, in mm10 reference.

本数据集的样本取自两株不同人类供体来源的患者来源异种移植（patient-derived xenograft, PDX）模型中的小鼠细胞。其中，HBCx-22与HBCx-22-TamR数据集对应一对管腔型雌激素受体阳性（ER+）乳腺癌PDX模型的小鼠细胞：HBCx-22为他莫昔芬敏感株，HBCx-22-TamR为他莫昔芬耐药株。HBCx-95与HBCx-95-CapaR数据集则对应一株三阴性乳腺癌（triple-negative breast cancer, TNBC）的化疗获得性耐药肿瘤模型。该计数矩阵的行名为50,000-bp（50千碱基对）分箱区域，列名为对应单细胞的细胞条形码（barcode），矩阵中存储的是基于mm10参考基因组的原始计数数据。