The Israeli BAG

The BAG is quite large with 24 principal investigators covering almost all groups in Israel. The scientific topics are diverse and so different that depicting them in a short Abstract is extremely difficult. In this context BAG members are studying the parameters that govern protein assemblage, structural impacts of signaling processes in different cascades. There are several projects that are directed towards molecular recognition with implementation towards drug design. In addition, we still have the ribosome project and the design of unique antibiotics with specific functional interactions from the mycinamycins family and their resistance related mechanism compared with other macrolides and the photosystem and how it converts light into energy. Since Covid-19 is still a relevant topic as are other viral infections BAG members are and have been involved in the understanding of the infection process and the means to hinder it.

BAG课题组规模庞大，拥有24名首席研究员，覆盖以色列境内几乎所有相关研究团队。该课题组的研究主题极为多元繁杂，以至于在简短的摘要中对其进行全面概述几乎难以实现。在此背景下，BAG成员正围绕调控蛋白质组装的参数、不同信号级联反应中信号转导过程的结构影响展开研究。另有多项聚焦分子识别的研究项目，旨在将成果应用于药物开发。此外，课题组还开展了核糖体（ribosome）研究项目；同时致力于设计具备特异性功能相互作用的新型抗生素，研究对象涵盖枝霉素（mycinamycins）家族，并对比其与其他大环内酯类抗生素的耐药相关机制；此外还围绕光系统（photosystem）及其光能转化机制展开研究。鉴于新冠疫情（COVID-19）与其他病毒感染仍是当前的研究热点，BAG成员此前及目前均参与了病毒感染过程及其阻断手段的相关研究。