Analysis of the body temperature during five days after challenge of ferrets immunized with H2N2 LAIV strains.

1The Area Under Curve was deduced from the area under curve (after challenge) above the baseline (38.0 ± 0.7 °C) temperature (before challenge);2The maximum temperature increase represents the highest recorded increase in temperature above the baseline during any of the measurements after challenge;3Number of the temperature loggers used for the calculations. Initially all ferrets we implanted with a transponder, but after recovery the measurements of some of the transponders could not be retrieved, due to battery or recording failure;*indicates significant difference compared to placebo group (pThe body temperature was recorded at intervals of 30 minutes by an intraperitoneally implanted temperature transponder.