Danish crystallography BAG

Despite PI changes, the BAG will continue to work on diverse areas of structural biology, ranging from fundamental of enzyme mechanisms, structure-based engineering of enzymes for industrial applications, particularly involving degradation and transformation of plant biomass, and viral, microbial and mammalian proteins involved in different aspects of health and disease. Among the specific targets are glycosyltransferases, fluorinases, sterol and sugar transporters, NS5B, Keap1, lytic polysaccharide monooxygenases, glucuronylesterases, phage repressor peptidase, alginate degrading polysaccharide lyases, mucin degrading glycosylhydrolases, type V autotransporters.

尽管首席研究员（Principal Investigator，PI）发生变动，BAG仍将持续在结构生物学的多个细分领域开展研究，涵盖酶促机制的基础研究、面向工业应用的酶结构导向改造（尤其涉及植物生物质的降解与转化），以及与健康和疾病不同环节相关的病毒、微生物及哺乳动物蛋白质。具体研究靶点包括糖基转移酶（glycosyltransferases）、氟化酶（fluorinases）、固醇与糖转运蛋白（sterol and sugar transporters）、NS5B、Keap1、溶菌多糖单加氧酶（lytic polysaccharide monooxygenases）、葡萄糖醛酸酯酶（glucuronylesterases）、噬菌体阻遏肽酶（phage repressor peptidase）、藻酸盐降解多糖裂解酶（alginate degrading polysaccharide lyases）、黏蛋白降解糖苷水解酶（mucin degrading glycosylhydrolases）以及V型自转运蛋白（type V autotransporters）。