PathMap Experiment #000023 - Tags: #TDP-43 pathology #RNA Splicing #Stathmin 2 #Vitreous Body #DNA-Binding Protein-43

Interactive Data Viewer: Read, View, and Print from Day 1 Use our fully interactive viewer to view, read, and print this research data right from Day 1: https://pathmap.org/viewer.php?id=23 Artificial General Intelligence LLC Claim Evaluated: Does misfolded TDP43 affect Retinal Ganglion Cell STMN2 ability to repair in a similar way as what how it was shown to affect motor neurons with cryptic mis-splicing? This dataset contains the raw JSON execution trace, verified verbatim quotes, and MeSH-aligned logic gates generated by PathMap Studio's Veridical Enforcement engine. 🧪 Extracted Custom Datapoints 📊 Suggested Experiments Perform single-nuclei RNA sequencing (snRNA-seq) on retinal ganglion cells from TDP-43 mutant mouse models to assess STMN2 splicing profiles. Evaluate axonal regeneration capacity of RGCs derived from human iPSCs with TDP-43 knockdown vs. controls after optic nerve crush injury. 📊 Suggested Studies Comparative proteomics of RGCs in FTLD-TDP patient postmortem tissue to quantify STMN2 protein depletion. Longitudinal study of vitreous STMN2 levels and retinal thinning in presymptomatic C9orf72 mutation carriers. 📊 Swansons Literature Based Discovery Candidates TDP-43-induced STMN2 depletion impairs the regenerative potential of optic nerve fibers, potentially contributing to retinal pathology in ALS. TDP-43 loss of function leads to STMN2 mis-splicing and impaired axonal repair in motor neurons (Source: 40392845). Vitreous fluid in ALS/FTD patients shows reduced STMN2 levels, implying ocular-associated neurodegeneration (Source: 41180957). STMN2 protein, which is vital for microtubule dynamics and axonal regeneration. Since STMN2 is essential for axon regeneration in neurons and its levels are known to decline in the vitreous of TDP-43 pathology patients, it is mechanistically plausible that mis-splicing of STMN2 similarly inhibits the regenerative repair of retinal ganglion cell axons. 📊 Contradictions Between Evidences None identified in the current literature set. 📊 Repurposed Solutions Antisense oligonucleotides (ASOs) that correct STMN2 cryptic splicing in motor neurons could be repurposed for local intravitreal administration to preserve retinal ganglion cell health. 🔖 Tags Attractor Table Extracted Keywords & Entities TDP-43 pathology, _gates_from_tdp-43_pathology, RNA Splicing, _gates_to_rna_splicing, _gates_from_rna_splicing, Stathmin 2, _gates_to_stathmin_2, Vitreous Body, _gates_to_vitreous_body, DNA-Binding Protein-43, _gates_from_dna-binding_protein-43, Retinal Ganglion Cells, _gates_to_retinal_ganglion_cells, Cell Nucleus, _gates_from_cell_nucleus, _gates_from_stathmin_2, Axonal Degeneration, _gates_to_axonal_degeneration, Axons, _gates_to_axons, _gates_from_axons 🚀 Run Your Own Analysis PathMap is a patent-pending universal AI workbench designed to eliminate LLM hallucinations in medical research. Generate your own autonomous discovery reports at PathMap.org.