“One-Pot” Approach to 8‑Acylated 2‑Quinolinones via Palladium-Catalyzed Regioselective Acylation of Quinoline N‑Oxides

A “one-pot” facile and efficient protocol for 8-acylated 2-quinolinones has been developed through palladium-catalyzed acylation of quinoline N-oxides, which proceeds with high selectivity at the C8-position. The desired products were isolated in up to 95% yield and good functional group tolerance. A palladacycle was isolated from the catalytic process and proposed as a key intermediate.