Extracellular microRNA Biomarkers for Diagnostic and Prognostic Assessment of Preeclampsia at Triage

This study is comprised of samples from 123 donors (71 cases and 52 controls) undergoing evaluation for preeclampsia. All samples were collected between 20 and 40 weeks of gestation. Small RNA sequencing was done on serum RNA obtained from donors. We were able to identify 3 bivariate extracellular miRNA biomarkers that can enable early diagnosis of preeclampsia. The raw fastq small-RNA sequencing fastq files will be submitted to dbGaP.]]>
Inclusion Criteria: • Pregnant women age ≥ 18 • Prenatal care at UC San Diego Prenatal Care Clinics • Singleton pregnancy • Gestational age between 20 and 0/7 and 40 and 6/7 weeks gestational age • Undergoing evaluation for suspected pulmonary embolism (PE)Exclusion Criteria: • Previous admission during the current pregnancy for suspected PE • Previously diagnosed during the current pregnancy with severe preterm PE • Plan for immediate delivery • Admission to the hospital for other indications with post-admission development of signs or symptoms requiring evaluation for PE ]]>