Gene expression data from aortic tissues of PPE-AAA mice receiving systemic lenvatinib treatment

Abdominal aortic aneurysm (AAA) is a disease with high morbidity and mortality, especially when ruptured. The rationale of this study was to evaluate the repurposing of lenvatinib, a multi–tyrosine kinase inhibitor, in limiting experimental AAA growth targeting vascular smooth muscle cells (VSMCs) and angiogenesis. We applied systemic lenvatinib treatment to porcine pancreatic elastase(PPE)-induced murine aortic aneurysms and profiled their gene expression through Affymetrix MTA1-0 microarray. Three separate groups (nondilated control aorta, PPE-AAA, PPE-AAA+Lenvatinib systemic treatment; same region of infrarenal aorta in all animals) of mouse aortic tissues were analyzed for differential expression.