Density measurements of different receptors for Area TE 2.1 (STG) [human, v1.0]

This dataset contains the densities (in fmol/mg protein) of receptors for classical neurotransmitters in Area TE 2.1 (STG) obtained by means of quantitative _in vitro_ autoradiography. The receptor densities are visualized as _fingerprints_ (**fp**), which provide the mean density and standard deviation for each of the analyzed receptor types, averaged across samples. Overview of available measurements [ **receptor** \| **_neurotransmitter_** \| _labeling agent_ ]: **AMPA** \| **_glutamate_** \| _[³H]AMPA_ **kainate** \| **_glutamate_** \| _[³H]kainate_ **NMDA** \| **_glutamate_** \| _[³H]MK-801_ **mGluR2/3** \| **_glutamate_** \| _[³H]LY341495_ **GABA_A** \| **_GABA_** \| _[³H]muscimol_ **GABA_B** \| **_GABA_** \| _[³H]CGP54626_ **GABA_A/BZ** \| **_GABA_** \| _[³H]flumazenil_ **muscarinic M₁** \| **_acetylcholine_** \| _[³H]pirenzepine_ **muscarinic M₂** \| **_acetylcholine_** \| _[³H]oxotremorine-M_ **muscarinic M₃** \| **_acetylcholine_** \| _[³H]4-DAMP_ **nicotinic α₄β₂** \| **_acetylcholine_** \| _[³H]epibatidine_ **α₁** \| **_noradrenalin/norepinephrine_** \| _[³H]prazosin_ **α₂** \| **_noradrenalin/norepinephrine_** \| _[³H]UK-14,304_ **5-HT_1A** \| **_serotonin_** \| _[³H]8-OH-DPAT_ **5-HT₂** \| **_serotonin_** \| _[³H]ketanserin_ **D₁** \| **_dopamine_** \| _[³H]SCH23390_ Information on the used tissue samples and corresponding subjects for the receptor fingerprints, profiles and autoradiographs as well as a list of analyzed receptors accompanies the provided dataset. **For methodological details, see:** Zilles, K. et al. (2002). Quantitative analysis of cyto- and receptorarchitecture of the human brain, pp. 573-602. In: Brain Mapping: The Methods, 2nd edition (A.W. Toga and J.C. Mazziotta, eds.). San Diego, Academic Press. Palomero-Gallagher N, Zilles K. (2018) Cyto- and receptorarchitectonic mapping of the human brain. In: Handbook of Clinical Neurology 150: 355-387 **The receptor density data of this area were also published in:** Morosan P, Rademacher J, Palomero-Gallagher N, and Zilles K (2005) Anatomical organization of the human auditory cortex: Cytoarchitecture and transmitter receptors. In Heil P, Scheich H, Bundinger E, and König R (Eds), The Auditory Cortex - Towards a Synthesis of Human and Animal Research. (pp. 27-50) [Mahwah, New Jersey, USA: Lawrence Erlbaum Associates](https://www.taylorfrancis.com/books/e/9781135613365/chapters/10.4324%2F9781410613066-9)

本数据集包含通过定量体外放射自显影术获得的TE 2.1区（颞上回，Superior Temporal Gyrus，简称STG）内经典神经递质受体的密度（单位：飞摩尔每毫克蛋白，fmol/mg protein）。
该受体密度以**指纹图谱（fingerprints，简称fp）**的形式可视化呈现，涵盖所有分析过的受体类型的平均密度与标准差，且数值已跨样本取平均。
可用测量指标概览 [ **受体类型** | **_神经递质_** | **_标记试剂_** ]：
**AMPA受体** | **_谷氨酸（glutamate）_** | *[³H]AMPA*
**海人藻酸受体** | **_谷氨酸（glutamate）_** | *[³H]海人藻酸*
**NMDA受体** | **_谷氨酸（glutamate）_** | *[³H]MK-801*
**代谢型谷氨酸受体2/3（mGluR2/3）** | **_谷氨酸（glutamate）_** | *[³H]LY341495*
**GABAₐ受体** | **_γ-氨基丁酸（GABA）_** | *[³H]蝇蕈醇（muscimol）*
**GABAᵦ受体** | **_γ-氨基丁酸（GABA）_** | *[³H]CGP54626*
**GABAₐ/苯二氮䓬复合受体** | **_γ-氨基丁酸（GABA）_** | *[³H]氟马西尼（flumazenil）*
**毒蕈碱型M₁受体** | **_乙酰胆碱（acetylcholine）_** | *[³H]哌仑西平（pirenzepine）*
**毒蕈碱型M₂受体** | **_乙酰胆碱（acetylcholine）_** | *[³H]氧代震颤素-M（oxotremorine-M）*
**毒蕈碱型M₃受体** | **_乙酰胆碱（acetylcholine）_** | *[³H]4-DAMP*
**烟碱型α₄β₂受体** | **_乙酰胆碱（acetylcholine）_** | *[³H]依匹哌啶（epibatidine）*
**α₁肾上腺素能受体** | **_去甲肾上腺素（noradrenalin/norepinephrine）_** | *[³H]哌唑嗪（prazosin）*
**α₂肾上腺素能受体** | **_去甲肾上腺素（noradrenalin/norepinephrine）_** | *[³H]UK-14,304*
**5-羟色胺1A受体（5-HT₁A）** | **_5-羟色胺（serotonin）_** | *[³H]8-OH-DPAT*
**5-羟色胺2受体（5-HT₂）** | **_5-羟色胺（serotonin）_** | *[³H]酮色林（ketanserin）*
**多巴胺D₁受体** | **_多巴胺（dopamine）_** | *[³H]SCH23390*
本数据集同步提供了受体指纹图谱、受体谱图与放射自显影图像所使用的组织样本及对应受试者的相关信息，同时附带已分析受体的完整列表。
如需了解方法学细节，请参阅：
Zilles, K. 等（2002）。人类大脑细胞构筑与受体构筑的定量分析，第573-602页。载于：《脑成像技术方法（Brain Mapping: The Methods）》第二版（A.W.托加（A.W. Toga）与J.C.马齐奥塔（J.C. Mazziotta）主编）。圣地亚哥：学术出版社（Academic Press）。
Palomero-Gallagher N, Zilles K.（2018）。人类大脑的细胞构筑与受体构筑图谱。载于：《临床神经病学手册（Handbook of Clinical Neurology）》第150卷：第355-387页。
本脑区的受体密度数据也曾发表于：
Morosan P, Rademacher J, Palomero-Gallagher N, 与Zilles K.（2005）。人类听觉皮层的解剖组织：细胞构筑与递质受体。载于：Heil P, Scheich H, Bundinger E, 与König R.主编，《听觉皮层——实现人类与动物研究的综合（The Auditory Cortex - Towards a Synthesis of Human and Animal Research）》。（第27-50页）[美国新泽西州马瓦：劳伦斯·埃尔鲍姆联合出版社（Lawrence Erlbaum Associates）](https://www.taylorfrancis.com/books/e/9781135613365/chapters/10.4324%2F9781410613066-9)