Association of TLR-pathway polymorphisms with cytokine responses following BCG vaccination in discovery cohort.^a

aWhole blood from 10-week old infants vaccinated at birth with BCG was re-stimulated with BCG ex vivo for 7 hours and plasma levels of IFN-γ, IL-2, and IL-13 were measured in a discovery cohort sample set (n = 240). bP value calculated from a general linear model that examined whether TLR polymorphisms were associated with BCG-induced cytokine levels after subtraction of unstimulated control values.