Fine particulate matter (PM2.5) promotes IgE-mediated mast cell activation through ROS/Gadd45b/JNK axis

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Conclusions: PM2.5 regulates ROS production through Gadd45b/MEKK4/JNK pathway, facilitating IgE-mediated mast cell activation.

结论：细颗粒物（PM2.5）通过Gadd45b/MEKK4/JNK信号通路调控活性氧（ROS）的生成，进而促进免疫球蛋白E（IgE）介导的肥大细胞活化。