In vivo transcriptomic responses to mercury chloride exposure in rat kidney tissue

In this study we tested the ability to predict organ injury from transcriptomics data in Sprague-Dawley rats at early time points after exposure to mercury chloride (10 and 34 hours). We selected mercury chloride, a compound extensively used in animal studies for its ability to cause acute kidney and liver damage.本研究针对暴露于氯化汞（mercury chloride）后的斯普拉格-道利大鼠（Sprague-Dawley rats），在暴露后的早期时间点（10小时与34小时），基于转录组学数据（transcriptomics data）评估了其器官损伤的预测能力。本研究选取氯化汞作为受试化合物，因其可诱导急性肝肾损伤，且该化合物已被广泛应用于动物实验研究。