Profiling pancreatic islets from obese db/db and lean control db/+ mice

This program addresses the molecular basis of beta-cell failure associated with the development of type 2 diabetes in the db/db mice. Specifically, which genes are differentially expressed in pancreatic islets of the db/db mice compared to the control db/+ mice? The db/db mice islets profiling data was analyzed by identifying genes that were up- and down-regulated at selected p value and fold change in the islets of db/db mice compared to the corresponding db/+ controls.本研究聚焦db/db小鼠中与2型糖尿病（type 2 diabetes）发生发展相关的β细胞（beta-cell）衰竭的分子机制。具体而言，本研究旨在明确相较于对照db/+小鼠，db/db小鼠胰岛（pancreatic islets）中存在哪些差异表达基因。本研究通过筛选预设的P值（p value）与倍数变化（fold change）阈值，对db/db小鼠的胰岛表达谱数据展开分析，鉴定出相较于对应db/+对照小鼠，db/db小鼠胰岛中上调及下调的差异表达基因。