Mmp-13 deletion in cells of the mesenchymal lineage increases bone mass, decreases endocortical osteoclast number and attenuates the cortical bone loss caused by estrogen deficiency in mice

We generated mice with conditional Mmp-13 deletion in Prrx1 expressing cells (Mmp-13dPrrx1) and compared the effect of estrogen deficiency on their bone phenotype to that of control littermates (Mmp-13f/f) We compare transcriptome of calvaria cells between Mmp13 knock out mice with wildtype