Morphological, molecular and functional cardiac study during aging in animals submitted to gestational protein restriction

Conclusion: The present study suggests that maternal protein restriction may lead to early heart disorders in the LP offspring compared to the NP group. We may hypothesize that rapid heart dysfunction is associated with heart fibrosis, myocardial cell hypertrophy and multiple gene expression abnormalities in the LP offspring.结论：本研究表明，与NP组（NP group）相比，母体蛋白质限制可能导致LP组子代（LP offspring）出现早期心脏功能异常。我们据此提出假说：LP组子代的快速发作性心脏功能障碍与心脏纤维化、心肌细胞肥大及多种基因表达异常存在关联。