cryo-EM of human GLP-1R bound to non-peptide agonist LY3502970
收藏Protein Data Bank Japan2024-11-13 更新2026-03-21 收录
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cryo-EM of human GLP-1R bound to non-peptide agonist LY3502970 Descriptor: 3-[(1S,2S)-1-(5-[(4S)-2,2-dimethyloxan-4-yl]-2-{(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carbonyl}-1H-indol-1-yl)-2-methylcyclopropyl]-1,2,4-oxadiazol-5(4H)-one, Alpha subunit of Gs with N-terminus swapped with equivalent residues in Gi,Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas, Glucagon-like peptide 1 receptor, ... Authors: Sun, B, Kobilka, B.K, Sloop, K.W, Feng, D, Kobilka, T.S. Deposit date: 2020-07-07 Release date: 2020-11-18 Last modified: 2024-11-13 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist. Proc.Natl.Acad.Sci.USA, 117, 2020
创建时间：
2020-07-07
