Summary of data from this study.

(A) Overview of the CpGs in the emQTL communities. (B) Overview of the genes in each emQTL community. (C) Enrichment of genes in gene sets from the MSigDB by community. Only gene sets with a significant enrichment after BH-correction are shown. (D) Reactome pathway enrichment analysis using the gene sets obtained from each emQTL community. (E) Enrichment of CpGs in community 1–6 in Encode-defined cis-regulatory elements defined by ENCODE. (F) Enrichment of CpGs in community 1–6 in UniBind-defined TFBRs. Only TFs showing a statistically significant enrichment are shown. (G) Enrichment of emQTL in community 1–6 in GeneHancer-defined chromatin loops and IM-PET loops. (H) Candidate cancer-promoting emQTL related to the regulation of metabolism, proliferation, and hormone-signaling. p-values and r-values obtained from Pearson correlation between DNA methylation at CpGs and expression levels of genes are included for the discovery and validation dataset from the TCGA-PANCAN dataset. R-values obtained from the correlation analysis in the 33 different TCGA-PANCAN cancer types independently are annotated to indicate if the correlation was significant after BH correction. (I) Enrichment emQTL -CpGs in Segway-defined regulatory regions in the PANC-1 and HepG2 cell lines by community. (XLSX)