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Crystal Structure of human phosphorylated IRE1alpha in complex with a type III kinase inhibitor (GSK2850163A)

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Protein Data Bank Japan2023-09-27 更新2026-03-21 收录
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https://pdbj.org/mine/summary/4yz9
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Crystal Structure of human phosphorylated IRE1alpha in complex with a type III kinase inhibitor (GSK2850163A) Descriptor: (5R)-2-(3,4-dichlorobenzyl)-N-(4-methylbenzyl)-2,7-diazaspiro[4.5]decane-7-carboxamide, Serine/threonine-protein kinase/endoribonuclease IRE1 Authors: Concha, N.O. Deposit date: 2015-03-24 Release date: 2015-11-11 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.463 Å) Cite: Long-Range Inhibitor-Induced Conformational Regulation of Human IRE1 alpha Endoribonuclease Activity. Mol.Pharmacol., 88, 2015
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2015-03-24
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