Dynamic Methylome Modification associated with mutational signatures in ageing and etiology of disease

Epigenetic markers and reversible change in the loci of genes regulating critical cell processes have recently emerged as important biomarkers in the study of disease pathology. The epigenetic changes that accompany ageing in the context of population health risk need to be explored. Additionally, the interplay between dynamic methylation changes that accompany ageing in relation to mutations that accrue in an individual genome over time needs further investigation. Our current study captures the role for variants acting in concurrence with dynamic methylation in an individual analyzed over time, in essence reflecting the genome-epigenome interplay, affecting biochemical pathways controlling physiological processes.