Supplementary tables: Healthcare and economic burden of anticholinergic use in adults with overactive bladder: a systematic literature review

<b>These are peer-reviewed supplementary materials for the article '</b><b>Healthcare and economic burden of </b><b>anticholinergic use in adults with </b><b>overactive bladder: a systematic literature </b><b>review</b><b>' published in the</b><b> </b><b><i>Journal of Comparative Effectiveness Research</i></b><b>.</b><b>Supplementary Table 1: </b>Search strategy<b>Supplementary Table 2: </b>Quality evaluation of observational studies<b>Supplementary Table 3: </b>Quality evaluation of economic studies<b>Supplementary Table 4: </b>Detailed reporting of HCRU outcomes<b>Supplementary Table 5: </b>Detailed reporting of cost outcomes<b>Aim: </b>To determine the economic burden associated with anticholinergic medication use in adults with overactive bladder (OAB) in the USA. <b>Methods:</b> A systematic literature review was conducted to identify articles assessing healthcare resource utilization (HCRU) and costs associated with anticholinergic use in adults with OAB.<b> Results:</b> From the 34 articles identified, increased anticholinergic burden, switching anticholinergic treatments and potentially inappropriate anticholinergic use were associated with increased HCRU and/or costs. However, studies comparing patients with OAB receiving anticholinergics to individuals with untreated OAB or without OAB reported a mix of increases and decreases in HCRU and costs. <b>Conclusion:</b> Additional controlled studies assessing the economic impact of anticholinergics in OAB are needed and may enable optimization of economic and potentially patient outcomes.

本文件为发表于《Journal of Comparative Effectiveness Research》（《比较效果研究杂志》）的论文《成人膀胱过度活动症患者抗胆碱能药物使用的医疗负担与经济负担：一项系统文献综述》的同行评议补充材料。
补充表1：检索策略
补充表2：观察性研究质量评价
补充表3：经济学研究质量评价
补充表4：医疗资源利用（Healthcare Resource Utilization, HCRU）结局详细报告
补充表5：成本结局详细报告
研究目的：明确美国成人膀胱过度活动症（Overactive Bladder, OAB）患者使用抗胆碱能药物相关的经济负担。
研究方法：本研究开展系统文献综述，筛选评估成人OAB患者抗胆碱能药物使用相关医疗资源利用（Healthcare Resource Utilization, HCRU）与成本的相关文献。
研究结果：本次共纳入34篇文献，结果显示，抗胆碱能药物负担加重、更换抗胆碱能治疗方案以及潜在不恰当使用抗胆碱能药物均与HCRU升高和/或成本增加相关。不过，对比接受抗胆碱能药物治疗的OAB患者与未接受治疗的OAB患者或非OAB人群的相关研究，则得出了HCRU与成本升降不一的混合结果。
研究结论：未来仍需开展更多评估抗胆碱能药物在OAB治疗中经济影响的对照研究，以优化医疗经济结局并改善患者预后。