Expression profiling PDE4B inhibitor BI 1015550 treatment in a therapeutic Rat Lung Bleomycin Model

Idiopathic pulmonary fibrosis (IPF) is a progressing chronic and fibrotic lung response with poor prognosis. To study the underlying molecular mechanisms of IPF, the rat bleomycin model is commonly used. Intratracheal application of bleomycin is known to induce inflammatory and fibrotic processes in the lung, e.g. infiltratin of inflammatory cells and collagen deposition. Recently, the PDE4B inhibitor BI 1015550 has been reported to prevent a decrease in lung function in patients with IPF. Here we examined the effect of PDE4 inhibitor BI 1015550 in the rat bleomycin model on transcriptional level by RNASeq.特发性肺纤维化（Idiopathic Pulmonary Fibrosis, IPF）是一种预后不良的进行性慢性纤维化肺部病变。为探究IPF潜在的分子机制，博莱霉素大鼠模型是当前常用的研究模型。经气管内给予博莱霉素可诱导肺部炎症与纤维化进程，具体包括炎性细胞浸润及胶原沉积。近期有研究表明，磷酸二酯酶4B（PDE4B）抑制剂BI 1015550能够延缓IPF患者的肺功能下降。本研究通过RNA测序（RNA-seq）技术，检测了PDE4抑制剂BI 1015550在博莱霉素大鼠模型中对转录水平的影响。