A Magnetic Resonance Imaging Contrast Agent Capable of Detecting Hydrogen Peroxide
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https://figshare.com/articles/dataset/A_Magnetic_Resonance_Imaging_Contrast_Agent_Capable_of_Detecting_Hydrogen_Peroxide/2491705
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资源简介：
The redox-active ligand N-(2-hydroxy-5-methylbenzyl)-N,N′,N′-tris(2-pyridinylmethyl)-1,2-ethanediamine
(Hptp1) was prepared and complexed to manganese(II). The isolated
[Mn(Hptp1)(MeCN)]2+ serves as a magnetic resonance imaging
contrast agent, with an r1 value comparable
to those of other mononuclear gadolinium(III) and manganese(II) complexes.
The metal and ligand are stable in aerated aqueous solutions, but
the addition of H2O2 causes the complex to oxidatively
couple to itself through a bimolecular reaction involving the phenol
groups of two Hptp1 ligands. The binuclear product is less paramagnetic
per manganese(II) than its mononuclear precursor, lowering the measured r1 per manganese(II). The manganese(II) complex
with Hptp1 can thereby serve as a sensor for oxidative stress.
创建时间：
2017-01-02
