Additional file 1: of DNA methylation in a Scottish family multiply affected by bipolar disorder and major depressive disorder

Table S1. Sample demographic information for the individuals included in this study. Table S2. Comparison of 12 normalisation methods. Table S3. Probes attaining an uncorrected p-value of ≤ 0.05 in the comparison of individuals carrying the linked haplotype (LH) and married in controls (MI), ranked by p-value. Table S4. Probes attaining an uncorrected p-value of ≤ 0.05 in the comparison of affected individuals carrying the linked haplotype (ALH) and married in controls (MI), ranked by p-value. Table S5. Probes attaining an uncorrected p-value of ≤ 0.05 in the comparison of unaffected individuals carrying the linked haplotype (ULH) and married in controls (MI), ranked by p-value. Table S6. Probes attaining an uncorrected p-value of ≤ 0.05 in the comparison of affected individuals carrying the linked haplotype (ALH) and unaffected carriers of the linked haplotype (ULH), ranked by p-value. Table S7. Differentially methylated regions (DMRs) identified in affected carriers of the linked haplotye(ALH) compared to married in controls (MI), ranked by p-value. Table S8. Differentially methylated regions (DMRs) identified in carriers of the linked haplotye (LH) compared to married in controls (MI), ranked by p-value. Table S9. Differentially methylated regions (DMRs) identified in unaffected carriers of the linked haplotye (ULH) compared to married in controls (MI), ranked by p-value. Table S10. Differentially methylated regions (DMRs) identified in affected carriers of the linked haplotye (ALH) compared to unaffected carriers of the linked haplotype (ULH), ranked by p-value. Table S11. Significantly enriched molecular process gene ontology (GO) categories identified in the ALH vs. MI comparison. Table S12. Significantly enriched biological function gene ontology (GO) categories identified in the ALH vs. MI comparison. Table S13. Significantly enriched cellular component gene ontology (GO) categories identified in the ALH vs. MI comparison. Table S14. Significantly enriched molecular process gene ontology (GO) categories identified in the ULH vs. MI comparison. Table S15. Significantly enriched biological function gene ontology (GO) categories identified in the ULH vs. MI comparison. Table S16. Significantly enriched cellular component gene ontology (GO) categories identified in the ULH vs. MI comparison. Table S17. Significantly enriched molecular process gene ontology (GO) categories identified in the ALH vs. ULH comparison. Table S18. Significantly enriched biological function gene ontology (GO) categories identified in the ALH vs. ULH comparison. Table S19. Significantly enriched molecular process gene ontology (GO) categories identified in the LH vs. MI comparison. Table S20. Significantly enriched biological function gene ontology (GO) categories identified in the LH vs. MI comparison. Table S21. Significantly enriched cellular component gene ontology (GO) categories identified in the LH vs. MI comparison. Table S22. Details of the qRT-PCR assays used to measure the seven reference genes assessed for the stability of their expression using geNorm [75]. XLSX 8646 kb)

补充表S1：本研究纳入个体的样本人口统计学信息。
补充表S2：12种标准化方法的对比分析。
补充表S3：在携带连锁单倍型（linked haplotype）的个体与婚配对照（married in controls，MI）的对比中，未校正p值≤0.05的探针，按p值排序。
补充表S4：在携带连锁单倍型的患病个体（affected individuals carrying the linked haplotype，ALH）与婚配对照（MI）的对比中，未校正p值≤0.05的探针，按p值排序。
补充表S5：在携带连锁单倍型的未患病个体（unaffected carriers of the linked haplotype，ULH）与婚配对照（MI）的对比中，未校正p值≤0.05的探针，按p值排序。
补充表S6：在携带连锁单倍型的患病个体（ALH）与携带连锁单倍型的未患病个体（ULH）的对比中，未校正p值≤0.05的探针，按p值排序。
补充表S7：在携带连锁单倍型的患病个体（ALH）与婚配对照（MI）的对比中鉴定得到的差异甲基化区域（differentially methylated regions，DMRs），按p值排序。
补充表S8：在携带连锁单倍型（linked haplotype，LH）的个体与婚配对照（MI）的对比中鉴定得到的DMRs，按p值排序。
补充表S9：在携带连锁单倍型的未患病个体（ULH）与婚配对照（MI）的对比中鉴定得到的DMRs，按p值排序。
补充表S10：在携带连锁单倍型的患病个体（ALH）与携带连锁单倍型的未患病个体（ULH）的对比中鉴定得到的DMRs，按p值排序。
补充表S11：在ALH与MI的对比中鉴定得到的显著富集的分子进程基因本体（Gene Ontology，GO）类别。
补充表S12：在ALH与MI的对比中鉴定得到的显著富集的生物学功能GO类别。
补充表S13：在ALH与MI的对比中鉴定得到的显著富集的细胞组分GO类别。
补充表S14：在ULH与MI的对比中鉴定得到的显著富集的分子进程GO类别。
补充表S15：在ULH与MI的对比中鉴定得到的显著富集的生物学功能GO类别。
补充表S16：在ULH与MI的对比中鉴定得到的显著富集的细胞组分GO类别。
补充表S17：在ALH与ULH的对比中鉴定得到的显著富集的分子进程GO类别。
补充表S18：在ALH与ULH的对比中鉴定得到的显著富集的生物学功能GO类别。
补充表S19：在LH与MI的对比中鉴定得到的显著富集的分子进程GO类别。
补充表S20：在LH与MI的对比中鉴定得到的显著富集的生物学功能GO类别。
补充表S21：在LH与MI的对比中鉴定得到的显著富集的细胞组分GO类别。
补充表S22：用于通过geNorm工具[75]评估7个参考基因表达稳定性的实时定量聚合酶链式反应（quantitative real-time polymerase chain reaction，qRT-PCR）实验细节。文件格式为XLSX，大小为8646 KB。