Erratum: Intussusceptive Angiogenesis: A Biologically Relevant Form of Angiogenesis

Angiogenesis, i.e. the development and growth of blood vessels, is a major topic of research as it plays an important role in normal development and in various pathologies. Recent evidence revealed the existence of different mechanisms of blood vessel growth, including sprouting and intussusceptive angiogenesis, vascular mimicry, and blood vessel cooption. The latter two have only been observed in tumor growth, but sprouting and intussusceptive angiogenesis also occur in healthy, physiologically growing tissues. Despite this variety of angiogenic mechanisms, most of the current research is focused on the mechanism of sprouting angiogenesis because this mechanism was first described and because most existing experimental models are related to sprouting angiogenesis. Consequently, the mechanism of intussusceptive angiogenesis is often overlooked in angiogenesis research. Here, the mechanism of intussusceptive angiogenesis is reviewed and the current techniques and models for investigating intussusceptive angiogenesis are summarized. In addition, other mechanisms of vascular growth are briefly reviewed.

血管生成（Angiogenesis），即血管的发育与生长过程，是当前研究的核心议题之一，因其在正常发育及多种病理状态中发挥关键作用。近年来的研究证实，血管生长存在多种不同机制，包括出芽血管生成（sprouting angiogenesis）、套叠式血管生成（intussusceptive angiogenesis）、血管拟态（vascular mimicry）以及血管共选择（blood vessel cooption）。后两种机制仅在肿瘤生长过程中被观测到，而出芽血管生成与套叠式血管生成同样存在于健康的生理性生长组织中。尽管血管生成机制存在上述多样性，但当前多数研究均聚焦于出芽血管生成机制，这一方面是因为该机制最早被报道，另一方面则是由于现有多数实验模型均与出芽血管生成相关。因此，套叠式血管生成机制在血管生成研究中常被忽视。本文将对套叠式血管生成机制进行综述，并总结当前用于研究该机制的实验技术与模型。此外，本文还将简要概述其他血管生长机制。