Compound 8, containing a triazolopyridine, showed better selectivity profiling than compound 3.
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IC50 values were obtained as described in the Methods Section. The values reported are an average of two independent data points. Inhibitors were used at a final concentration of 10 µMa (3) and 5 µMb (8), respectively. cThis designation indicates that the improvement in percentage of inhibition was greater than 50%. IC50 values were obtained as described in the Methods Section. Details of assay conditions can be found at www.ProQinase.com.
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2015-12-02
