Crystal structure of HPK1 T165E/S171E in complex with compound 13
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Crystal structure of HPK1 T165E/S171E in complex with compound 13 Descriptor: 5-(methylamino)-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[(4-morpholin-4-ylphenyl)amino]pyrazine-2-carboxamide, Mitogen-activated protein kinase kinase kinase kinase 1 Authors: Schimpl, M, Pflug, A. Deposit date: 2024-10-29 Release date: 2025-02-19 Last modified: 2025-03-05 Method: X-RAY DIFFRACTION (1.631 Å) Cite: Discovery and Optimization of Pyrazine Carboxamide AZ3246, a Selective HPK1 Inhibitor. J.Med.Chem., 68, 2025
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2024-10-29
