Statistically significant results of an association analysis between SNPs of non-HLA genes and clinical baseline characteristics of patients

Analysis of the SNPs genotype frequencies and the initial clinical characteristics of the patients in our sample revealed associations for a number of genes and loci. However, when adjusting for multiple hypothesis testing, no significant associations were revealed. The table presents the loci and genes with significant associations with the initial clinical and biochemical parameters. The study of correlations of genotype frequencies with clinical characteristics and biochemical parameters of the patients revealed significant associations mainly for non-HLA genes. The HLA-B27 genotypes were significantly associated only with elevated anti-CCP level (p=0.008). While PADI4 [rs11203367, rs2240340, rs11203366, rs874881], AMPD1 [rs17602729], IL23R [rs10889671, rs11465770], IL4R [rs1801275], IL4 [rs2243250], IL6 [rs2069849] were significantly associated with the severity of the disease (DAS28, CDAI, HAQ-DI). MTHFR [rs180113] and DHODH [rs3213422] were associated with CRP level; IRAK3 [rs11541076], IL2RA [rs2104286], IL4R [rs1801275] were associated with the rheumatoid factor (RF) level and IL23R [rs7539625, rs7530511, rs10889671], IL2RB [rs3218253], IL6R [rs 2228144], STAT4 [rs7574865], TNFRSF1A [rs767455, rs1800693] are associated with anti-CCP level.